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VEGFR2 Kinase Inhibitor II

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产品名称: VEGFR2 Kinase Inhibitor II
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简单介绍

CAS:288144-20-7Formula:C17H15BrN2OMW:343.2Appearance:BrownSolidPurity:95%


VEGFR2 Kinase Inhibitor II  的详细介绍
A membrane permeant indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor . The inhibition is suggested to be competitive with respect to ATP. Also inhibits VEGF-induced (IC = 100 nM) and PDGF-induced (IC = 2.01 M)cell proliferation in umbilical vein endothelial cells (HUVEC). Does not exhibit any inhibitory effect on EGF-R kinase activity (IC 100 M).

Additional Information

SynonymsVascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor II
Product #V-1080
CAS #288144-20-7
Chemical Name(Z)-5-Bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one
FormulaC17H15BrN2O
MW343.2
AppearanceBrown Solid
Purity95%
SolubilitySoluble in DMSO
Storage Temp-20°C

Additional Information

MDL NumberMFCD03453583
InChIInChI=1S/C17H15BrN2O/c18-11-5-6-13-14(17(21)20-16(13)8-11)9-12-7-10-3-1-2-4-15(10)19-12/h5-9,19H,1-4H2,(H,20,21)/b14-9-
SMILESc1cc\2c(cc1Br)NC(=O)/C2=C\c3cc4c([nH]3)CCCC4
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