Vandetanib

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产品名称: Vandetanib

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简单介绍

CAS:443913-73-3Formula:C22H24BrFN4O2MW:475.35Appearance:WhiteSolidPurity:98%byHPLC

Vandetanib 的详细介绍

A potent inhibitor of kinase insert domain-containing receptor tyrosine kinase activity (IC= 40 nM). This compound also inhibits fms-like tyrosine kinase 4 (VEGFR3, IC= 110 nM) and epidermal growth factor receptor (EGFR/HER1, IC= 500 nM) but shows selectivity relating to a range of other tyrosine and serine-threonine kinases.

Additional Information

Synonyms	N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine; ZD6474, Zactima
Product #	V-2475
CAS #	443913-73-3
Chemical Name	N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine; ZD6474, Zactima
Formula	C₂₂H₂₄BrFN₄O₂
MW	475.35
Appearance	White Solid
Purity	98% by HPLC
Solubility	DMSO (30 mg/ml) or EtOH (10 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Vandetanib is an antagonist of VEGFR (Flk and Flk) and EGFR families

Additional Information

MDL Number	MFCD07772346
ChemACX	X1614613-9
InChI	InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
SMILES	CN1CCC(CC1)COc2cc3c(cc2OC)c(ncn3)Nc4ccc(cc4F)Br

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