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Valinomycin

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产品名称: Valinomycin
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简单介绍

CAS:2001-95-8Formula:C54H90N6O18C54H90N6O18MW:1111.34Appearance:WhitecrystallinepowderPurity:98.47%byHPLC&99%byTLC


Valinomycin  的详细介绍

Valinomycin is an antibiotic which acts as a potassium (K+) ionophore. Induces K+ conductivity in cell membranes. Also active in vitro against Mycobacterium Tuberculosis, and as an apoptosis inducer.

Valinomycin is used diagnostically in ion selective electrodes because of its preferential ability to conduct K+ across the electrodes membrane. Valinomycin induced stimulation of mitochondrial energy dependent reversible swelling, supported by succinate oxidation, cytochrome c (cyto-c) and sulfite oxidase (Sox) (both are present in the mitochondrial intermembrane space (MIS)) are released outside.Valinomycin also inhibits hyphal growth in other dimorphic fungi, Candida tropicalis and Aureobasidium pullulan. It affects the morphology of Candida albicans.

 

Additional Information

Product #V-1013
CAS #2001-95-8
Chemical Name(2S,8R,11S,14S,17R,20R,23S,26S,29R,32R,35S)-2,14,26-TRIMETHYL-5,8,11,17,20,23,29,32,35-NONA(PROPAN-2-YL)-3,9,15,21,27,33-HEXAOXA-6,12,18,24,30,36-HEXAZACYCLOHEXATRIACONTANE-1,4,7,10,13,16,19,22,25,28,31,34-DODECONE
FormulaC54H90N6O18 C54H90N6O18
MW1111.34
AppearanceWhite crystalline powder
Purity98.47% by HPLC & 99% by TLC
SolubilitySoluble in Acetic Acid, CHCl3, DMSO or Ether.
Melting Point374 °C
Storage Temp+4°C
Therapeutic AreaPulmonary Disorders
UseValinomycin is potent agent against severe acute respiratory-syndrome coronavirus (SARS-CoV) in infected Vero E6 cells

Additional Information

Merck IndexMerck Index: 13.9978.2001
MDL NumberMFCD00005114
ChemACXX1008618-5
InChIInChI=1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34+,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1
SMILESC[C@H]1C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O[C@H](C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O[C@H](C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O1)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C
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