UNC0638

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产品名称: UNC0638

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简单介绍

CAS:1255580-76-7Formula:C30H47N5O2MW:509.72Appearance:Off-whitesolidPurity:≥98%byHPLC

UNC0638 的详细介绍

Cell-permeable. UNC0638 is a potent G9a HMTase inhibitor, exhibiting an IC₅₀ value of 50 value of 19 nM, but is more than 10,000-fold selective against SET7/9 (a H3K4 HMTase), SET8 (a H4K20 HMTase), PRMT3, and SUV39H2. UNC0638 inhibits H3K9 dimethylation in MDA-MB231 cells with an IC₅₀ value of 81 nM and demonstrates favorable separation of functional and toxic effect.

Additional Information

Product #	U-2473
CAS #	1255580-76-7
Chemical Name	2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
Formula	C₃₀H₄₇N₅O₂
MW	509.72
Appearance	Off-white solid
Purity	≥98% by HPLC
Solubility	DMSO (10 mM)
Storage Temp	-20°C

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