产品资料

Tozasertib

如果您对该产品感兴趣的话,可以
产品名称: Tozasertib
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

CAS:639089-54-6Formula:C23H28N8OSMW:464.59Appearance:Whitetooff-whiteSolidPurity:99%byHPLC


Tozasertib  的详细介绍
Tozasertib inhibits Aurora kinases A, B and C with Ki values of 0.6, 18 and 4.6 nM, respectively. It also inhibits Flt-3 and Abl as well as their mutant forms.

Additional Information

SynonymsMK-0457, VX6, VX-681
Product #T-2466
CAS #639089-54-6
Chemical NameN-(4-(4-(3-METHYL-1H-PYRAZOL-5-YLAMINO)-6-(4-METHYLPIPERAZIN-1-YL)PYRIMIDIN-2-YLTHIO)PHENYL)CYCLOPROPANECARBOXAMIDE
FormulaC23H28N8OS
MW464.59
AppearanceWhite to off-white Solid
Purity99% by HPLC
SolubilityDMSO (100 mg/ml)
Melting Point245-260 °C
Storage Temp-20°C
Therapeutic AreaOncological Disorders
UseTozasertib is a potent pan-ARK inhibitor but favors ARK-1.Tozasertib effectively inhibits proliferation of renal carcinoma

Additional Information

MDL NumberMFCD13185152
ChemACXX1653617-5
InChIInChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)
SMILESCc1cc(n[nH]1)Nc2cc(nc(n2)Sc3ccc(cc3)NC(=O)C4CC4)N5CCN(CC5)C
产品留言
标题
联系人
联系电话
内容
验证码
点击换一张
注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

沪公网安备 31011202007337号