Thiolutin

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产品名称: Thiolutin

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简单介绍

CAS:87-11-6Formula:C8H8N2O2S2MW:228.29Appearance:Brilliantyellowneedlelikecrystals.Purity:98%

Thiolutin 的详细介绍

Thiolutin is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. It was found to inhibit in vitro RNA synthesis directed by all three yeast RNA polymerases (I, II, and III). Thiolutin is also an inhibitor of mannan and glucan formation in Saccharomyces cerevisiae and used for the analysis of mRNA stability.

Additional Information

Synonyms	Farcinicin, Propiopyvothine, Acetopyrrothine
Product #	T-1226
CAS #	87-11-6
Chemical Name	N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)
Formula	C₈H₈N₂O₂S₂
MW	228.29
Appearance	Brilliant yellow needle like crystals.
Purity	98%
Solubility	Soluble in Dichloromethane or Methanol, DMSO (0.5%). 1 mg/ml of Thiolutin in DMSO gives a clean orange solution.
Melting Point	184.48 °C
Storage Temp	+4°C
Therapeutic Area	Infectious Diseases
Use	Thiolutin is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases

Additional Information

MDL Number	MFCD01076610
ChemACX	X1191506-1
InChI	InChI=1S/C8H8N2O2S2/c1-4(11)9-6-7-5(3-13-14-7)10(2)8(6)12/h3H,1-2H3,(H,9,11)
SMILES	CC(=O)Nc1c-2sscc2n(c1=O)C

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