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TDZD-8 |GSK-3 beta Inhibitor I Pathway for Alzheimer treatment |CAS#327036-89-5

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产品名称: TDZD-8 |GSK-3 beta Inhibitor I Pathway for Alzheimer treatment |CAS#327036-89-5
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简单介绍

CAS:327036-89-5Formula:C10H10N2SO2MW:222.3Appearance:Off-WhitePowderPurity:95%HPLC


TDZD-8 |GSK-3 beta Inhibitor I Pathway for Alzheimer treatment |CAS#327036-89-5  的详细介绍
TDZD-8 is a highly selective, non-ATP competitive inhibitor of GSK-3b (IC50=2M). TDZD-8 Binds to the active site of GSK3b. TDZD-8 Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50100M). Potential Alzheimer's treatment.

Additional Information

Product #T-1132
CAS #327036-89-5
Chemical Name4-Benzyl-2-methyl-1,2,4,-thiadiazolidine-3,5-dione
FormulaC10H10N2SO2
MW222.3
AppearanceOff-White Powder
Purity95% HPLC
SolubilityDMSO
PreparationFollowing reconstitution, aliquote at freeze at -20C. Stock solutions can store < 3 months at -20C.
Storage Temp+4°C
Therapeutic AreaNeurological Disorders
UseTDZD-8 is a highly selective, non-ATP competitive inhibitor of GSK-3b.Potential Alzheimer's treatment

Additional Information

MDL NumberMFCD04973552
ChemACXX1437396-7
InChIInChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
SMILESCn1c(=O)n(c(=O)s1)Cc2ccccc2
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