TAK 165

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产品名称: TAK 165

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简单介绍

CAS:366017-09-6Formula:C25H23F3N4O2MW:468.47Appearance:Whitetooff-whiteSolidPurity:98%byHPLC

TAK 165 的详细介绍

Cell-permeable. A potent inhibitor of the human epidermal growth factor receptor 2 (HER2) tyrosine kinase (IC= 6 nM). Displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. TAK 165 inhibits bladder, kidney and androgen-independent prostate cancer in vitro and in vivo.

Additional Information

Synonyms	(E)-4-((4-)1H-1,2,3-Triazol-1-yl)butyl)phenoxy)methyl)-2-(4-trifluoromethyl)oxazole; Mubritinib
Product #	T-2450
CAS #	366017-09-6
Chemical Name	(E)-4-((4-)1H-1,2,3-Triazol-1-yl)butyl)phenoxy)methyl)-2-(4-trifluoromethyl)oxazole; Mubritinib
Formula	C₂₅H₂₃F₃N₄O₂
MW	468.47
Appearance	White to off-white Solid
Purity	98% by HPLC
Solubility	DMSO (~25 mg/ml) or EtOH (~ 1.7 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	A selective, potent, and irreversible ErbB2 and EGFR inhibitor use in cancer

Additional Information

MDL Number	MFCD09954135
ChemACX	X1722551-1
InChI	InChI=1S/C25H23F3N4O2/c26-25(27,28)21-9-4-20(5-10-21)8-13-24-30-22(18-34-24)17-33-23-11-6-19(7-12-23)3-1-2-15-32-16-14-29-31-32/h4-14,16,18H,1-3,15,17H2/b13-8+
SMILES	c1cc(ccc1CCCCn2ccnn2)OCc3coc(n3)/C=C/c4ccc(cc4)C(F)(F)F

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