Mycotoxin that inhibits DNA synthesis. Induces sister chromatid exchanges in bone marrow cells of mice. Causes necrosis. ST exerts a marked influence on gastric mucus and gland cells, showing dominant gastritis, erosion events, polyps, and intestinal metaplasia in these animals.1 Long-term administration of the fungus toxin, sterigmatocystin, induces intestinal metaplasia and increases the proliferative activity of PCNA, p53, and MDM2 in the gastric mucosa of aged Mongolian gerbils. M Kusunoki, J Misumi, et al, Jul 2011; 16(4): 224-31.
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