Sitagliptin Phosphate Monohydrate

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产品名称: Sitagliptin Phosphate Monohydrate

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简单介绍

CAS:654671-77-9Formula:C16H15F6N5OH3PO4H2OMW:523.32Appearance:WhiteSolidPurity:98%byHPLC

Sitagliptin Phosphate Monohydrate 的详细介绍

Sitagliptin is an anti-diabetic (antihyperglycemic) drug of the dipeptidyl peptidase-4 (DPP-4) class. Sitagliptin inhibition of the enzyme DPP-4 is thought to increase Glucagon-like peptide-1 (GLP-1) which inhibits glucagon release. Sitagliptin stimulates the insulin release and lowers blood glucose.

Additional Information

Synonyms	7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate; MK-0431
Product #	S-2435
CAS #	654671-77-9
Chemical Name	7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate; MK-0431
Formula	C₁₆H₁₅F₆N₅OH₃PO₄H₂O
MW	523.32
Appearance	White Solid
Purity	98% by HPLC
Solubility	Soluble in H₂O
Storage Temp	-20°C
Therapeutic Area	Endocrinological Disorders
Use	A potent, orally active inhibitor of DPP-IV used in type 2 diabetes

Additional Information

MDL Number	MFCD10001393
ChemACX	X1611286-0
InChI	InChI=1S/C16H15F6N5O.H3O4P.H2O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22;1-5(2,3)4;/h4,6,9H,1-3,5,7,23H2;(H3,1,2,3,4);1H2/t9-;;/m1../s1
SMILES	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.O.OP(=O)(O)O

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