SIRT2 Inhibitor, AGK2

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产品名称: SIRT2 Inhibitor, AGK2

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简单介绍

CAS:304896-28-4Formula:C23H13Cl2N3O2MW:434.27Appearance:YellowSolidPurity:95%byHPLC

SIRT2 Inhibitor, AGK2 的详细介绍

A potent inhibitor of sirtuin 2 (SIRT2) (IC= 3.5 M). AGK2 is 15-fold more selective for SIRT2 than SIRT1 and SIRt3. Inhibition of SIRT2 rescued synuclein toxicity and modified inclusion morphology in a cellular model of Parkinsons disease.

Additional Information

Synonyms	AGK2, (2E)-2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-(quinolin-5-yl)prop-2-enamide
Product #	S-2434
CAS #	304896-28-4
Chemical Name	AGK2, (2E)-2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-(quinolin-5-yl)prop-2-enamide
Formula	C₂₃H₁₃Cl₂N₃O₂
MW	434.27
Appearance	Yellow Solid
Purity	95% by HPLC
Solubility	Soluble in DMSO
Storage Temp	+4°C
Therapeutic Area	Neurological Disorders
Use	A reversible inhibitor of SIRT2 activity,a histone deacetylase enzyme

Additional Information

MDL Number	MFCD01909444
ChemACX	X1621483-2
InChI	InChI=1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+
SMILES	c1cc2c(cccn2)c(c1)NC(=O)/C(=C/c3ccc(o3)c4cc(ccc4Cl)Cl)/C#N

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