Simvastatin

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产品名称: Simvastatin

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简单介绍

CAS:79902-63-9Formula:C25H38O5MW:418.6Appearance:WhitetoOff-WhiteSolidPurity:98%

Simvastatin 的详细介绍

HMG-CoA reductase inhibitor. Simvastatin inhibits the biosynthesis of isoprenoids and prevents small G protein activation. Displays lipid lowering and antihypertensive effects. Displays antiinflammatory, immunomodulatory effects as well as protective effects in experimental traumatic brain injury. Activates Rac1-dependent signaling pathway.Simvastatin Induces Heme Oxygenase-1: A Novel Mechanism of Vessel Protection.

Additional Information

Synonyms	Synvinolin, MK-733
Product #	S-2004
CAS #	79902-63-9
Chemical Name	(1S,3R,7S,8S,8AR)-8-(2-[(2R,4R)-4-HYDROXY-6-OXOTETRAHYDRO-2H-PYRAN-2-YL]ETHYL)-3,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL 2,2-DIMETHYLBUTANOATE
Formula	C₂₅H₃₈O₅
MW	418.6
Appearance	White to Off-White Solid
Purity	98%
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml); insoluble in water.
Melting Point	127-132 °C
Storage Temp	-20°C
Therapeutic Area	Vascular Disorders, Metabolic Disorders
Use	Simvastatin is an HMGCR (HMG-CoA reductase) inhibitor used in the treatment of hypercholesterolemia

Additional Information

MDL Number	MFCD00072007
ChemACX	X1000597-9
InChI	InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
SMILES	CC[C@@](C(=O)O[C@@H]1[C@H]2C(=C[C@@H](C1)C)C=C[C@@H]([C@@H]2CC[C@H]3OC(=O)C[C@@H](C3)O)C)(C)C

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