SCD1 Inhibitor

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产品名称: SCD1 Inhibitor

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简单介绍

Formula:C20H22ClN3O3MW:387.86Appearance:CrystallineSolidPurity:95%byHPLC

SCD1 Inhibitor 的详细介绍

Cell-permeable. A potent and selective inhibitor of SCD1(stearoyl-CoA desaturase 1) (In vitro: IC= 37 nM for hSCD1, 4 nM for mSCD1). Also exhibited in vivo efficacy with dose-dependent desaturation index lowering effect. SCD1 inhibition resulted in alterations in macrophage membrane lipid composition and marked hypersensitivity to toll-like receptor 4 agonists.

Additional Information

Synonyms	4-(2-Chlorophenoxy)-N-(3-(3-methylcarbamoyl)phenyl)piperidine-1-carboxamide
Product #	S-2427
Chemical Name	4-(2-Chlorophenoxy)-N-(3-(3-methylcarbamoyl)phenyl)piperidine-1-carboxamide
Formula	C₂₀H₂₂ClN₃O₃
MW	387.86
Appearance	Crystalline Solid
Purity	95% by HPLC
Solubility	DMSO (~ 180 mg/ml)
Storage Temp	-20°C

Additional Information

InChI	InChI=1S/C20H22ClN3O3/c1-22-19(25)14-5-4-6-15(13-14)23-20(26)24-11-9-16(10-12-24)27-18-8-3-2-7-17(18)21/h2-8,13,16H,9-12H2,1H3,(H,22,25)(H,23,26)
SMILES	CNC(=O)C1=CC(=CC=C1)NC(=O)N2CCC(CC2)OC3=CC=CC=C3Cl

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