S-2122, SB-431542, An inhibitor of the TGF-β 1 receptor ALK5, CAS# 301836-41-9,

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产品名称: S-2122, SB-431542, An inhibitor of the TGF-β 1 receptor ALK5, CAS# 301836-41-9,

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简单介绍

CAS:301836-41-9Formula:C22H16N4O3MW:384.39Appearance:CrystallineSolidPurity:98%

S-2122, SB-431542, An inhibitor of the TGF-β 1 receptor ALK5, CAS# 301836-41-9, 的详细介绍

A potent and selective inhibitor of the TGF- 1 receptor ALK5 (IC= 94 nM). It inhibits ALK4 only at higher concentrations (IC= 140 nM). Suppresses renewal in embryonic and induced pluripotent stem (iPS) cells and promotes their differentiation through its effect on Smad signaling pathway.

Additional Information

Synonyms	4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
Product #	S-2122
CAS #	301836-41-9
Chemical Name	4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
Formula	C₂₂H₁₆N₄O₃
MW	384.39
Appearance	Crystalline Solid
Purity	98%
Solubility	DMSO (20 mg/ml) or Ethanol (2 mg/ml)
Melting Point	315.72 °C
Storage Temp	Store at -20°C. Protect from air and light
Therapeutic Area	Oncological Disorders
Use	A specific and selective inhibitor of TGF-ß type I ALK receptors and Smad3.It also suppressed the TGF-beta-induced proliferation of osteosarcoma

Additional Information

MDL Number	MFCD05865244
ChemACX	X1430393-8
InChI	InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
SMILES	c1ccnc(c1)c2c(nc([nH]2)c3ccc(cc3)C(=O)N)c4ccc5c(c4)OCO5

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