SB-203580

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产品名称: SB-203580

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简单介绍

CAS:152121-47-6Formula:C21H16N3FOSMW:377.4Appearance:WhitetoOff-WhiteSolidPurity:≥98%

SB-203580 的详细介绍

SB-203580 is a pyridinyl imidazole which acts as a specific inhibitor of p38 MAP Kinase. SB-203580 does not inhibit the MAP kinase homologs JNK and p42 MAP kinase.

* Listed below are a few published articles demonstrating the use of our SB-203580. Inquire for a full list of references.

A New Isoquinolinium Derivative, Cadein1, Preferentially Induces Apoptosis in p53-defective Cancer Cells with Functional Mismatch Repair via a p38-dependent Pathway, Eun Ryoung Jang, Minsook Ryu, et al. J. Biol. Chem. Jan 2010. 285: 2986 - 2995.
Glycogen Synthase Kinase-3 Plays a Central Role in Mediating Glucocorticoid-Induced Apoptosis, Rachel Spokoini, Shlomit Kfir-Erenfeld, et al. Mol. Endocrinol. Jun 2010. 24: 1136 - 1150.
Sequential phosphorylation of insulin receptor substrate-2 by glycogen synthase kinase-3 and c-Jun NH2-terminal kinase plays a role in hepatic insulin signaling, Hadar Sharfi and Hagit Eldar-Finkelman. Am J Physiol Endocrinol Metab. Feb 2008. 294: E307 - E315.

Additional Information

Product #	S-1014
CAS #	152121-47-6
Chemical Name	4-(4-Fluorophenyl)-2-(4-methylsulfinyl phenyl)-5-(4-pyridyl) 1H-imidazole
Formula	C₂₁H₁₆N₃FOS
MW	377.4
Appearance	White to Off-White Solid
Purity	≥98%
Solubility	Soluble in DMSO (50mg/ml) or methanol.
Storage Temp	-20°C, Warning! Irritant. May be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Protect from Light.

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