Saracatinib

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产品名称: Saracatinib

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简单介绍

CAS:379231-04-6Formula:C27H32ClN5O5MW:542.03Appearance:CrystallineSolidPurity:99%byHPLC

Saracatinib 的详细介绍

AZD0530 is a dually active inhibitor of c-Src and Bcr-ABL, on bone resorption. AZD0530 inhibited tumor growth in a manner independent of dose and inhibited phosphorylation of focal adhesion kinase (FAK) and paxillin in a dose-dependent manner in a Calu-6 Xenograft model.

Additional Information

Synonyms	AZD-0530
Product #	S-2425
CAS #	379231-04-6
Chemical Name	N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYL-1-PIPERAZINYL)ETHOXY]-5-[(TETRAHYDRO-2H-PYRAN-4-YL)OXY]-4-QUINAZOLINAMINE
Formula	C₂₇H₃₂ClN₅O₅
MW	542.03
Appearance	Crystalline Solid
Purity	99% by HPLC
Solubility	DMSO (~ 200 mg/ml) or EtOH (~ 200 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Saracatinib is a Src inhibitor use in cancer

Additional Information

MDL Number	MFCD09832698
ChemACX	X1722059-2
InChI	InChI=1S/C27H32ClN5O5/c1-32-6-8-33(9-7-32)10-13-35-19-14-21-24(23(15-19)38-18-4-11-34-12-5-18)27(30-16-29-21)31-25-20(28)2-3-22-26(25)37-17-36-22/h2-3,14-16,18H,4-13,17H2,1H3,(H,29,30,31)
SMILES	CN1CCN(CC1)CCOC2=CC3=C(C(=C2)OC4CCOCC4)C(=NC=N3)NC5=C(C=CC6=C5OCO6)Cl

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