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S-Trityl-L-cysteine

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产品名称: S-Trityl-L-cysteine
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简单介绍

CAS:2799-07-7Formula:C22H21NO2SMW:363.5Appearance:Whitetooff-whiteSolid


S-Trityl-L-cysteine  的详细介绍
Potent, cell permeable cysteine thioether displaying anti-mitotic and anti-tumor properties. Inhibits mitosis by blocking basal and microtubule-activated ATPase activities of the mitotic kinesin Eg5 (IC50=1 uM and 140nm). Induces mitotic arrest in HeLa cells (IC50=700nM) and inhibits the growth of NCI tumor cell line panel (GI50=1.31 uM).

Additional Information

SynonymsTrityl-cysteine, NSC 83265
Product #T-1186
CAS #2799-07-7
Chemical Name(2R)-2-AMINO-3-TRITYLSULFANYLPROPANOIC ACID
FormulaC22H21NO2S
MW363.5
AppearanceWhite to off-white Solid
SolubilitySoluble in DMSO
Storage Temp-20°C
Therapeutic AreaOncological Disorders
UseS-Trityl-L-cysteine is a cell-permeable cysteine thioether compound that exhibits antitumor and antimitotic properties by inhibiting mitotic kinesin Eg5

Additional Information

MDL NumberMFCD00002611
ChemACXX1014343-0
InChIInChI=1S/C22H21NO2S/c23-20(21(24)25)16-26-22(17-10-4-1-5-11-17,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15,20H,16,23H2,(H,24,25)/t20-/m0/s1
SMILESc1ccc(cc1)C(c2ccccc2)(c3ccccc3)SC[C@@H](C(=O)O)N
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