RVX-208, BET bromodomain inhibitor

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产品名称: RVX-208, BET bromodomain inhibitor

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简单介绍

CAS:1044870-39-4Formula:C20H22N2O5MW:370.41Appearance:WhitesolidPurity:98%byTLCNMR(Conforms)

RVX-208, BET bromodomain inhibitor 的详细介绍

RVX-208 (1044870-39-4) is a potent BET bromodomain antagonist with IC₅₀ of 0.510 μM for BD2, with approximately 170-fold selectivity over BD1. RVX-208 increases apolipoprotein A-1 and HDL cholesterol in vitro and in vivo. Reduces atherosclerosis.

Additional Information

Synonyms	Apabetalone
Product #	R-2657
CAS #	1044870-39-4
Chemical Name	2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-4(3H)-quinzolinone
Formula	C₂₀H₂₂N₂O₅
MW	370.41
Appearance	White solid
Purity	98% by TLC NMR (Conforms)
Solubility	Soluble in DMSO (up to 75 mg/ml) or in Ethanol (up to 4 mg/ml).
Storage Temp	-20°C (des.)

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