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Rocaglamide

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产品名称: Rocaglamide
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简单介绍

CAS:84573-16-0Formula:C29H31NO7MW:505.56Appearance:Whitetooff-whiteSolidPurity:98%byHPLC


Rocaglamide  的详细介绍
An immunosuppressant and a potent inhibitor of NF-B activation in T cells, with an almost complete inhibition at 200 nM. Suppresses cytokine production (IFN-, TNF, IL-2 and IL-4) and inhibits NF-AT in peripheral blood T cells at concentrations that do not impair NF-B and AP-1 activities. Also induces mitochondria-mediated apoptosis in leukemia cells and sensitizes CD95/CD95L-mediated apoptosis in malignant T-cells by differential regulation of CD95L and c-FLIP expression.

Additional Information

SynonymsRocaglamide A
Product #R-2420
CAS #84573-16-0
Chemical Name(1R,2R,3S,3AR,8BS)-1,8B-DIHYDROXY-6,8-DIMETHOXY-3A-(4-METHOXYPHENYL)-N,N-DIMETHYL-3-PHENYL-2,3-DIHYDRO-1H-CYCLOPENTA[B][1]BENZOFURAN-2-CARBOXAMIDE
FormulaC29H31NO7
MW505.56
AppearanceWhite to off-white Solid
Purity98% by HPLC
SolubilitySoluble in DMSO or EtOH
Storage Temp-20°C
Therapeutic AreaOncological Disorders
UseRocaglamide is a potent anticancer agent 

Additional Information

MDL NumberMFCD08702699
ChemACXX1881329-5
InChIInChI=1S/C29H31NO7/c1-30(2)27(32)23-24(17-9-7-6-8-10-17)29(18-11-13-19(34-3)14-12-18)28(33,26(23)31)25-21(36-5)15-20(35-4)16-22(25)37-29/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1
SMILESCN(C)C(=O)[C@@H]1[C@H]([C@]2([C@@]([C@@H]1O)(c3c(cc(cc3OC)OC)O2)O)c4ccc(cc4)OC)c5ccccc5
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