Reversine

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产品名称: Reversine

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简单介绍

CAS:656820-32-5Formula:C12H27N7OMW:393.49Appearance:Off-WhiteSolidPurity:98%byTLC

Reversine 的详细介绍

A cell-permeable, potent, and selective human A adenosine receptor antagonist (K= 0.66M) and an aurora kinase inhibitor (IC of 30-550 nM for blast colony formation assay). Induces dedifferentiation in murine C2C12 myoblasts. Thye cells were also shown to regain multipluripotency following removal of the compound.

Additional Information

Synonyms	2-(4-Morpholinoanilino)-6-cyclohexylaminopurine
Product #	R-2034
CAS #	656820-32-5
Chemical Name	2-(4-Morpholinoanilino)-6-cyclohexylaminopurine
Formula	C₁₂H₂₇N₇O
MW	393.49
Appearance	Off-White Solid
Purity	98% by TLC
Solubility	Soluble in DMSO (~7-10 mg/ml)
Storage Temp	Store at -20°C
Therapeutic Area	Oncological Disorders
Use	Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells

Additional Information

MDL Number	MFCD09953189
ChemACX	X1494446-8
InChI	InChI=1S/C21H27N7O/c1-2-4-15(5-3-1)24-20-18-19(23-14-22-18)26-21(27-20)25-16-6-8-17(9-7-16)28-10-12-29-13-11-28/h6-9,14-15H,1-5,10-13H2,(H3,22,23,24,25,26,27)
SMILES	c1cc(ccc1Nc2nc3c(c(n2)NC4CCCCC4)nc[nH]3)N5CCOCC5

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