Rebeccamycin

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产品名称: Rebeccamycin

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简单介绍

CAS:93908-02-2Formula:C27H21Cl2N3O7MW:570.4Appearance:DullyellowlyophilisatePurity:>99%byHPLC

Rebeccamycin 的详细介绍

*Please inquire the availability for this product. Rebeccamycin is an indolocarbazole isolated from Lechevalieria aerocolonigenes. Rebeccamycin displays selective antitumor activity against several cell lines. Rebeccamycin's primary mechanism of action is via strong DNA intercalation resulting in the potent catalytic inhibition of both topoisomerases I and II. Analogues of rebeccamycin have been tested in clinical trials for cancer therapy.

Additional Information

Product #	R-2587
CAS #	93908-02-2
Formula	C27H21Cl2N3O7
MW	570.4
Appearance	Dull yellow lyophilisate
Purity	>99% by HPLC
Solubility	Soluble in DMSO (=3 mg/ml), THF, and methanol (=02 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	An indolocarbazole topoisomerase inhibitor shows significant antitumor properties

Additional Information

MDL Number	MFCD01718312
InChI	InChI=1S/C27H21Cl2N3O7/c1-38-24-13(8-33)39-27(23(35)22(24)34)32-20-10(5-3-7-12(20)29)15-17-16(25(36)31-26(17)37)14-9-4-2-6-11(28)18(9)30-19(14)21(15)32/h2-7,13,22-24,27,30,33-35H,8H2,1H3,(H,31,36,37)/t13-,22-,23-,24-,27-/m1/s1
SMILES	CO[C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O)n2c3c(cccc3Cl)c4c2c5c(c6cccc(c6[nH]5)Cl)c7c4C(=O)NC7=O)CO

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