Raf1 Kinase Inhibitor I

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产品名称: Raf1 Kinase Inhibitor I

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简单介绍

Formula:C15H8Br2INO2MW:520.9Appearance:DarkorangeSolidPurity:97%byHPLC

Raf1 Kinase Inhibitor I 的详细介绍

A potent cRAF1 kinase inhibitor (IC = 9 nM). Shows 100-fold selectivity for Raf kinase versus Cdk1, Cdk2, c-src, ERK2, MEK, p38, Tie2, VEGFR2, and c-Fms. cRAF1 inhibitors are predicted to be broad spectrum antitumor agents.

Additional Information

Product #	R-2020
Formula	C₁₅H₈Br₂INO₂
MW	520.9
Appearance	Dark orange Solid
Purity	97% by HPLC
Solubility	Soluble in DMSO (200 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Neurological Disorders
Use	An inhibitor of Raf-1 kinase and PMA-mediated activation of ERK1/2

Additional Information

MDL Number	MFCD03453076
ChemACX	X1342192-0
InChI	InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3+
SMILES	c1cc2c(cc1I)/C(=Cc3cc(c(c(c3)Br)O)Br)/C(=O)N2

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