PX-866

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产品名称: PX-866

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简单介绍

CAS:502632-66-8Formula:C29H35NO8MW:525.59Appearance:OrangeSolidPurity:98%byTLC

PX-866 的详细介绍

Cell-permeable. A derivative of Wortmannin (Cat. No. 1670-1), that potently and irreversibly inhibits PI 3-kinase with selectivity for p110 (IC= 0.1 nM). Displays antitumor activity.

Additional Information

Synonyms	DJM-166; DJM-2-166
Product #	P-2409
CAS #	502632-66-8
Chemical Name	(4S,4AR,5R,6AS,9AR,E)-1-((DIALLYLAMINO)METHYLENE)-11-HYDROXY-4-(METHOXYMETHYL)-4A,6A-DIMETHYL-2,7,10-TRIOXO-1,2,4,4A,5,6,6A,7,8,9,9A,10-DODECAHYDROINDENO[4,5-H]ISOCHROMEN-5-YL ACETATE
Formula	C₂₉H₃₅NO₈
MW	525.59
Appearance	Orange Solid
Purity	98% by TLC
Solubility	DMSO (~ 25 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	PX-866 inhibits tumor growth by blocking the PI 3-kinase pathway and cell motility

Additional Information

MDL Number	MFCD07784511
ChemACX	X1495745-0
InChI	InChI=1S/C30H37NO7/c1-7-11-31(12-8-2)15-19-21(33)13-18(16-37-6)30(5)25(19)28(36)27(35)24-20-9-10-23(34)29(20,4)14-22(26(24)30)38-17(3)32/h7-8,15,18,20,22,36H,1-2,9-14,16H2,3-6H3/b19-15-/t18-,20+,22-,29+,30+/m1/s1
SMILES	CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](CC(=O)/C(=C/N(CC=C)CC=C)/C4=C(C3=O)O)COC)C)C

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