Purmorphamine

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产品名称: Purmorphamine

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简单介绍

CAS:483367-10-8Formula:C31H32N6O2MW:520.6Appearance:BeigeSolidPackagedunderinertgasPurity:98%byHPLC

Purmorphamine 的详细介绍

A cell-permeable purine compound that induces osteoblast differentiation in C3H10T1/2 multipotent mesenchymal progenitor cells (EC = 1 M) and in MC3T3-E1 lineage-committed preosteoblasts. Also shown to induce transdifferentiation in pre-adipocytes and myoblasts. Its effects are reported to be synergistic with bone morphogenetic protein-4 (BMP-4). Reported to induce osteogenesis by activation of the Hedgehog signaling pathway.

Additional Information

Synonyms	Shh Signaling Agonist
Product #	P-1633
CAS #	483367-10-8
Chemical Name	2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine
Formula	C₃₁H₃₂N₆O₂
MW	520.6
Appearance	Beige Solid Packaged under inert gas
Purity	98% by HPLC
Solubility	DMSO (200 mg/ml)
Storage Temp	+4°C
Therapeutic Area	Musculoskeletal Disorders
Use	An activator of the hedgehog (Hh) signaling pathway induce osteogenesis in bone tissue

Additional Information

MDL Number	MFCD09037557
ChemACX	X1600485-6
InChI	InChI=1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)
SMILES	c1ccc2c(c1)cccc2Oc3nc(c4c(n3)n(cn4)C5CCCCC5)Nc6ccc(cc6)N7CCOCC7

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