An allosteric phosphoinositide-dependent protein kinase-1 (PDK1) activator (Kd =10.3 μM). Binds exlusively to the PIF-binding pocket of PDK1, distinct from the ATP . It has recently been found that a combination of PS48, sodium butyrate (Cat. No. 1609-1000), a histone deacetylase inhibitor and the gene Oct-4, could enhance the reprogramming efficiency of keratinocytes isolated from human skin or hair follicles over 25-fold.
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