Ponasterone A is an Insect steroid hormone involved in regulating metamorphosis. It is an analog of ecdysone A and a member of the ecdysteroid family with similar properties to muristerone A. It is a functional, reliable and economical substitute for muristerone A as an inducer for the ecdysone-inducible mammalian expression system.
Ponasterone A is a highly bioactive ligand that has demonstrated sustained release and transgene expression in vivo. Ponasterone A is a potent regulator of gene expression in cells and transgenic animals, enabling reporter genes to be turned on and off rapidly. It inhibits cell growth and increased cell number at the G1 phase. Treatment of cells with the synthetic ecdysone analog ponasterone A, induced expression of GFP-MKK7(3E) and resulted in sustained activation of endogenous JNK, but neither of the other endogenous MAPK's, ERK orp38.
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