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Piperlongumine
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产品名称:
Piperlongumine
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简单介绍
CAS:20069-09-4Formula:C17H19NO6MW:317.34Appearance:Whitetooff-whiteSolidPurity:97%
Piperlongumine
的详细介绍
A constituent of the pepper Piper longum L. that selectively kills cancer cells but not normal cells. Piperlongumine increases the level of reactive oxygen species (ROS) and apoptotic cell death in both cancer cells and normal cells engineered to have a cancer genotype, irrespective of p53 status, but it has little effect on either rapidly or slowly dividing primary normal cells. Also potently inhibits the growth of spontaneously formed malignant breast tumors and their associated metastases in mice.
Additional Information
Synonyms
(E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one; 1-[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-5,6-dihydropyridin-2(1H)-one; Piplartine
Product #
P-2399
CAS #
20069-09-4
Chemical Name
(E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one; 1-[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-5,6-dihydropyridin-2(1H)-one; Piplartine
Formula
C
17
H
19
NO
6
MW
317.34
Appearance
White to off-white Solid
Purity
97%
Solubility
DMSO (~ 25 mg/ml)
Melting Point
123-124 °C
Storage Temp
-20°C
Therapeutic Area
Oncological Disorders
Use
A selective anticancer GSTP1 inhibitor
Additional Information
MDL Number
MFCD00075706
ChemACX
X1095211-1
InChI
InChI=1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6-15(18)19/h4,6-8,10-11H,5,9H2,1-3H3/b8-7+
SMILES
COc1cc(cc(c1OC)OC)/C=C/C(=O)N2CCC=CC2=O
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