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Piperlongumine

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产品名称: Piperlongumine
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简单介绍

CAS:20069-09-4Formula:C17H19NO6MW:317.34Appearance:Whitetooff-whiteSolidPurity:97%


Piperlongumine  的详细介绍
A constituent of the pepper Piper longum L. that selectively kills cancer cells but not normal cells. Piperlongumine increases the level of reactive oxygen species (ROS) and apoptotic cell death in both cancer cells and normal cells engineered to have a cancer genotype, irrespective of p53 status, but it has little effect on either rapidly or slowly dividing primary normal cells. Also potently inhibits the growth of spontaneously formed malignant breast tumors and their associated metastases in mice.

Additional Information

Synonyms(E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one; 1-[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-5,6-dihydropyridin-2(1H)-one; Piplartine
Product #P-2399
CAS #20069-09-4
Chemical Name(E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one; 1-[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-5,6-dihydropyridin-2(1H)-one; Piplartine
FormulaC17H19NO6
MW317.34
AppearanceWhite to off-white Solid
Purity97%
SolubilityDMSO (~ 25 mg/ml)
Melting Point123-124 °C
Storage Temp-20°C
Therapeutic AreaOncological Disorders
UseA selective anticancer GSTP1 inhibitor

Additional Information

MDL NumberMFCD00075706
ChemACXX1095211-1
InChIInChI=1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6-15(18)19/h4,6-8,10-11H,5,9H2,1-3H3/b8-7+
SMILESCOc1cc(cc(c1OC)OC)/C=C/C(=O)N2CCC=CC2=O
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