Pimaricin, Streptomyces sp.

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产品名称: Pimaricin, Streptomyces sp.

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简单介绍

CAS:7681-93-8Formula:C33H47NO13MW:665.733Appearance:lightyellowSolidPurity:95%byHPLC

Pimaricin, Streptomyces sp. 的详细介绍

Pimaricin is a macrocyclic tetraene originally isolated from Streptomyces natalensis in 1957. Pimaricin exhibits broad spectrum antifungal activity against yeast and filamentous fungi by binding specifically to ergoesterol to block fungal growth. Unlike the related polyenes, nystatin and filipin, pimaricin does not change the permeability of the plasma membrane. Pimaricin is used in the food industry for surface treatment of cheeses as mold inhibitor.

Additional Information

Synonyms	Natamycin, Antibiotic A 5283, Delvolan, Delvocid, Delvopos, Mychophyt, Myprozine, Natacyn, Natafucin, Pimafucin, Pimafugin, Synogil, Tennecetin, Tymasil, A5263, CL 12625, E23
Product #	P-1637
CAS #	7681-93-8
Chemical Name	(1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-22-(((3S,4S,5S,6R)-4-AMINO-3,5-DIHYDROXY-6-METHYLTETRAHYDRO-2H-PYRAN-2-YL)OXY)-1,3,26-TRIHYDROXY-12-METHYL-10-OXO-6,11,28-TRIOXATRICYCLO[22.3.1.0(5,7)]OCTACOSA-8,14,16,18,20-PENTAENE-25-CARBOXYLIC ACID
Formula	C₃₃H₄₇NO₁₃
MW	665.733
Appearance	light yellow Solid
Purity	95% by HPLC
Solubility	Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Melting Point	280 °C
Storage Temp	-20°C
Therapeutic Area	Infectious Diseases
Use	An antifungal polyene macrolide is used to treat fungal infections

Additional Information

MDL Number	MFCD00135085
ChemACX	X1005609-4
InChI	InChI=1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39)28(34)29(38)19(2)44-32)15-25-27(31(40)41)22(36)17-33(42,47-25)16-20(35)14-24-23(46-24)12-13-26(37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3,(H,40,41)/b4-3+,7-5+,8-6+,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32+,33-/m1/s1
SMILES	C[C@@H]1C/C=C/C=C/C=C/C=C/[C@@H](C[C@H]2[C@@H]([C@H](C[C@](O2)(C[C@H](C[C@@H]3[C@H](O3)/C=C/C(=O)O1)O)O)O)C(=O)O)O[C@H]4[C@H]([C@H]([C@@H]([C@H](O4)C)O)N)O

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