Pifithrin-Alpha hydrobromide

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产品名称: Pifithrin-Alpha hydrobromide

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简单介绍

CAS:63208-82-2Formula:C16H18N2OS.BrHMW:367.3Appearance:Off-WhiteSolidPurity:98%

Pifithrin-Alpha hydrobromide 的详细介绍

Chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Reversibly blocks p53 dependent transcriptional activation and apoptosis.p53 Mediates Nontranscriptional Cell Death in Dopaminergic Cells in Response to Proteasome Inhibition.p53 Down-Regulates Phosphatase and Tensin Homologue Deleted on Chromosome 10 Protein Stability Partially through Caspase-Mediated Degradation in Cells with Proteasome Dysfunction.Histone Deacetylase InhibitorMediated Radiosensitization of Human Cancer Cells: Class Differences and the Potential Influence of p53.Early Single Cell Bifurcation of Pro- and Antiapoptotic States during Oxidative Stress.

Additional Information

Synonyms	1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide
Product #	P-1177
CAS #	63208-82-2
Chemical Name	1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide
Formula	C₁₆ H₁₈ N₂ O S . Br H
MW	367.3
Appearance	Off-White Solid
Purity	98%
Solubility	Soluble in DMSO, DMF, Methanol.
Melting Point	192.1-192.5 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	An inhibitor of p53 that reversibly blocks p53 dependent transcriptional activation and apoptosis

Additional Information

MDL Number	MFCD00417851
ChemACX	X1343322-2
InChI	InChI=1S/C16H18N2OS.BrH/c1-11-6-8-12(9-7-11)14(19)10-18-13-4-2-3-5-15(13)20-16(18)17;/h6-9,17H,2-5,10H2,1H3;1H
SMILES	Cc1ccc(cc1)C(=O)Cn2c3c(sc2=N)CCCC3.Br

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