Perifosine

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产品名称: Perifosine

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简单介绍

CAS:157716-52-4Formula:C25H53NO4PMW:462.66Appearance:Whitetooff-whiteSolidPurity:99%

Perifosine 的详细介绍

Belongs to an alkylphospholipid class of antineoplastic compounds that display potent antiproliferative activity in several in vitro and in vivo human tumor models. Perifosine induces apoptotic cell death in a variety of tumor cell lines. Apoptosis is induced in a time- and dose-dependent manner in U937 and Jurkat T human leukemia cell lines but not in normal vascular endothelial cells.

Additional Information

Synonyms	KRX-0402
Product #	P-2392
CAS #	157716-52-4
Chemical Name	1,1-DIMETHYLPIPERIDINIUM-4-YL OCTADECYL PHOSPHATE
Formula	C₂₅H₅₃NO₄P
MW	462.66
Appearance	White to off-white Solid
Purity	99%
Solubility	Soluble in H₂O (10 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	An alkylphospholipid which inhibits Akt activation and the anti-apoptotic MAPK pathway used for variety of cancers

Additional Information

MDL Number	MFCD00927554
ChemACX	X1600392-6
InChI	InChI=1S/C25H52NO4P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24-29-31(27,28)30-25-20-22-26(2,3)23-21-25/h25H,4-24H2,1-3H3/p+1
SMILES	CCCCCCCCCCCCCCCCCCOP(=O)(O)OC1CC[N+](CC1)(C)C

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