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PDGFRTyrosine Kinase Inhibitor II

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产品名称: PDGFRTyrosine Kinase Inhibitor II
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简单介绍

CAS:249762-74-1Formula:C21H18N2O3MW:346.4Appearance:SolidPurity:97%


PDGFRTyrosine Kinase Inhibitor II  的详细介绍
A cell permeable bis(1H-2-indolyl)-1-methanone compound that acts as a highly selective, ATP-competitive and reversible inhibitor of platelet-derived growth factor receptor tyrosine kinase. Also potently inhibits Flt3 activity. Sensitzes 32D cells to radiation-induced apoptosis and inhibits prliferation of TEL-Flt3-transfected BA-F3 cells. May also serce as a prodrug for of the PDGF Receptor Tyrosine Kinase Inhibitor I in cells.

Additional Information

Product #P-1687
CAS #249762-74-1
Chemical Name(5-BUTANOATE-1H-2-INDOLYL)(1H-2-INDOLYL)-METHANONE
FormulaC21H18N2O3
MW346.4
AppearanceSolid
Purity97%
SolubilityDMSO
Storage Temp+2°C to +8°C
UseA cell-permeable isothiourea compound that perturbs MreB function

Additional Information

MDL NumberMFCD06411445
InChIInChI=1S/C21H18N2O3/c1-2-5-20(24)26-15-8-9-17-14(10-15)12-19(23-17)21(25)18-11-13-6-3-4-7-16(13)22-18/h3-4,6-12,22-23H,2,5H2,1H3
SMILESCCCC(=O)Oc1ccc2c(c1)cc([nH]2)C(=O)c3cc4ccccc4[nH]3
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