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PDGFR Tyrosine Kinase Inhibitor III

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产品名称: PDGFR Tyrosine Kinase Inhibitor III
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简单介绍

CAS:205254-94-0Formula:C27H27N5O4MW:485.5Appearance:WhiteSolidPurity:97%


PDGFR Tyrosine Kinase Inhibitor III  的详细介绍
A cell-permeable piperazinyl-quinazoline carboxamide compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of PDGF receptor family of tyrosine kinases. Affects the activities of other kinases only at much higher concentrations. Reported to block the PDGF-BB induced proliferation of porcine aorta smooth muscle cells.

Additional Information

Synonyms4-(6,7-Dimethoxy-4-quinazolinyl)-N-(4-phenoxyphenyl)-1-piperazinecarboxamide
Product #P-1691
CAS #205254-94-0
Chemical Name4-(6,7-DIMETHOXY-QUINAZOLIN-4-YL)-PIPERAZINE-1-CARBOXYLIC ACID (4-PHENOXY-PHENYL)-AMIDE
FormulaC27H27N5O4
MW485.5
AppearanceWhite Solid
Purity97%
SolubilityDMSO
Melting Point292.08 °C
Storage TempAmbient temperatures only
UseAn ATP-competitive PDGFR inhibitor

Additional Information

MDL NumberMFCD09037549
ChemACXX4983433-7
InChIInChI=1S/C27H27N5O4/c1-34-24-16-22-23(17-25(24)35-2)28-18-29-26(22)31-12-14-32(15-13-31)27(33)30-19-8-10-21(11-9-19)36-20-6-4-3-5-7-20/h3-11,16-18H,12-15H2,1-2H3,(H,30,33)
SMILESCOC1=C(C=C2C(=C1)C(=NC=N2)N3CCN(CC3)C(=O)NC4=CC=C(C=C4)OC5=CC=CC=C5)OC
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