PD-98059

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产品名称: PD-98059

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简单介绍

CAS:167869-21-8Formula:C16H13NO3MW:267.3Appearance:PaletoYellowSolidPurity:95%

PD-98059 的详细介绍

Cell-permeable, potent and specific inhibitor of MAP Kinase (MEK or MAPK/ERK). By selectively blocking the activity of MEK, it also inhibits the phosphorylation and activation of MAP kinase.Transcriptional activation of the IL31 gene by NFAT and STAT6.Differential Role of PKC Isoforms in GnRH and Phorbol 12-Myristate 13-Acetate Activation of Extracellular Signal-Regulated Kinase and Jun N-Terminal Kinase.Glycogen Synthase Kinase-3 Plays a Central Role in Mediating Glucocorticoid-Induced Apoptosis.Effect of Oncostatin M on Uridine Diphosphate-5'-Glucuronosyltransferase 1A1 through Cross Talk with Constitutive Androstane Receptor.Loss of E-Cadherinmediated CellCell Contacts Activates a Novel Mechanism for Up-Regulation of the Proto-Oncogene.

Additional Information

Synonyms	2'-Amino-3'methoxyflavone
Product #	P-1019
CAS #	167869-21-8
Chemical Name	2'-Amino-3'methoxyflavone
Formula	C₁₆H₁₃NO₃
MW	267.3
Appearance	Pale to Yellow Solid
Purity	95%
Solubility	DMSO
Melting Point	164-165 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Potent and specific inhibitor of MAP Kinase (MEK or MAPK/ERK) use in cancer

Additional Information

MDL Number	MFCD00671789
ChemACX	X1038243-7
InChI	InChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
SMILES	COc1cccc(c1N)c2cc(=O)c3ccccc3o2

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