PD-173074

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产品名称: PD-173074

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简单介绍

CAS:219580-11-7Formula:C28H41N7O3MW:523.67Appearance:CrystallineSolidPurity:98%byTLC

PD-173074 的详细介绍

A potent and selective FGFR1 tyrosine kinase inhibitor (IC= 21.5 nM). Blocking of the FGFR signaling pathway by PD 173074 leads to self-renewal of stem cells via ERK1/2 activation. Treatment of FGF2-expressing human multipotent adipose-derived stem cells with PD173074 decreases dramatically their clonogenicity and differentiation potential.

Additional Information

Synonyms	N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N-(1,1-dimethylethyl)urea
Product #	P-2390
CAS #	219580-11-7
Chemical Name	N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N’-(1,1-dimethylethyl)urea
Formula	C₂₈H₄₁N₇O₃
MW	523.67
Appearance	Crystalline Solid
Purity	98% by TLC
Solubility	Soluble in DMSO (10 mg/ml)
Melting Point	82-85 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	The Fibroblast Growth Factor Receptor Inhibitor PD173074 Blocks Small Cell Lung Cancer

Additional Information

MDL Number	MFCD08705327
ChemACX	X1544144-6
InChI	InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)
SMILES	CCN(CC)CCCCNc1ncc2cc(c(nc2n1)NC(=O)NC(C)(C)C)c3cc(cc(c3)OC)OC

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