PD-0325901

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产品名称: PD-0325901

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简单介绍

CAS:391210-10-9Formula:C16H14F3IN2O4MW:482.2Appearance:Off-WhiteSolidPurity:98%byHPLC

PD-0325901 的详细介绍

A selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (IC=0.33 nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell differentiation and sustains self-renewal ofembryonic stem (ES) cells.

Additional Information

Product #	P-1703
CAS #	391210-10-9
Chemical Name	N-[(2R)-2,3-DIHYDROXYPROPOXY]-3,4-DIFLUORO-2-(2-FLUORO-4-IODO-ANILINO)BENZAMIDE
Formula	C₁₆H₁₄F₃IN₂O₄
MW	482.2
Appearance	Off-White Solid
Purity	98% by HPLC
Solubility	DMSO or Ethanol (~20 mg/ml)
Melting Point	117-119 °C
Storage Temp	Keep cool and dry. Store at -20°C
Therapeutic Area	Oncological Disorders
Use	An inhibitor of MEK and suppressor of ERK phosphorylation use in cancer

Additional Information

MDL Number	MFCD08435926
ChemACX	X1755696-6
InChI	InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
SMILES	C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOC[C@@H](CO)O

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