Pazopanib

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产品名称: Pazopanib

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简单介绍

CAS:444731-52-6Formula:C21H23N7O2SMW:437.52Appearance:Whitetooff-whiteSolidPurity:98%byHPLC

Pazopanib 的详细介绍

Cell-permeable. A potent and selective multi-targeted tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor and c-kit, key proteins responsible for tumor growth and angiogenesis.

Additional Information

Synonyms	GW-786034
Product #	P-2385
CAS #	444731-52-6
Chemical Name	5-[4-[(2,3-DIMETHYL-2H-INDAZOL-6-YL)-METHYL-AMINO]-PYRIMIDIN-2-YLAMINO]-2-METHYL-BENZENESULFONAMIDE
Formula	C₂₁H₂₃N₇O₂S
MW	437.52
Appearance	White to off-white Solid
Purity	98% by HPLC
Solubility	DMSO (~ 8 mg/ml)
Melting Point	301-313 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Pazopanib is a potent and selective multi-targeted tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (Flk-1), platelet-derived growth factor receptor (PDGFR) and c-kit

Additional Information

MDL Number	MFCD11616589
ChemACX	X1722103-5
InChI	InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)
SMILES	CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N

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