Panobinostat

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产品名称: Panobinostat

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简单介绍

CAS:404950-80-7Formula:C21H23N3O2MW:349.43Appearance:CrystallineSolidPurity:99%byHPLC

Panobinostat 的详细介绍

Panobinostat (LBH589) is a highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumour cell proliferation in vitro. The ICvalues of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective, B61HDAC1 and B12HDAC6 are 0.230.06, 28329, 754, 475 and 8912 nM, respectively. And to A2780 proliferation, ICvalue is 4.61.8 nM.

Additional Information

Synonyms	LBH589, LBN-589, NVP-LBH590
Product #	P-2380
CAS #	404950-80-7
Chemical Name	(E)-N-HYDROXY-3-[4-[[2-(2-METHYL-1H-INDOL-3-YL)ETHYLAMINO]METHYL]PHENYL]PROP-2-ENAMIDE
Formula	C₂₁H₂₃N₃O₂
MW	349.43
Appearance	Crystalline Solid
Purity	99% by HPLC
Solubility	DMSO
Melting Point	115 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	An HDAC inhibitor reported to inhibit human multiple myeloma cell lines

Additional Information

MDL Number	MFCD09833242
ChemACX	X1612494-6
InChI	InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+
SMILES	CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO

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