Oligomycin A mitochondrial ATPases Inhibitor, Oligomycin A lysosome acidificati

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产品名称: Oligomycin A mitochondrial ATPases Inhibitor, Oligomycin A lysosome acidificati

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简单介绍

CAS:579-13-5Formula:C45H74O11MW:791.1Appearance:WhitetoOff-whitepowder(Lyophilisate).Purity:95%

Oligomycin A mitochondrial ATPases Inhibitor, Oligomycin A lysosome acidificati 的详细介绍

Oligomycin A is a component of the oligomycin complex (O-1060). It is an inhibitor of ATP synthase. In oxidative phosphorylation research, it is used to prevent state 3 (phosphorylating) respiration. Oligomycin A inhibits ATP synthase by blocking its proton channel (Fo subunit), which is necessary for oxidative phosphorylation of ADP to ATP (energy production). The inhibition of ATP synthesis by oligomycin A will significantly reduce electron flow through the electron transport chain however, electron flow is not stopped completely due to a process known as proton leak or mitochondrial coupling. This process occurs due to the facilitated diffusion of protons into the mitochondrial matrix through an uncoupling protein such as thermogenin, or UCP1.

Oligomycin A stimulates lysosome acidification due to shunting of membrane potential. Induces apoptosis in a variety of cell types. Oligomycin A also induces autophagy in the IPLB-LdFB insect cell line.

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Additional Information

Product #	O-1063
CAS #	579-13-5
Chemical Name	(1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-22-ETHYL-7,11,14,15-TETRAHYDROXY-6'-((R)-2-HYDROXYPROPYL)-5',6,8,10,12,14,16,28,29-NONAMETHYL-3',4',5',6'-TETRAHYDRO-2,26-DIOXASPIRO[BICYCLO[23.3.1]NONACOSA[4,18,20]TRIENE-27,2'-
Formula	C₄₅H₇₄O₁₁
MW	791.1
Appearance	White to Off-white powder (Lyophilisate).
Purity	95%
Solubility	Soluble in ethanol, methanol, DMF, or DMSO. Poor water solubility.
Melting Point	140-141°C
Storage Temp	Store Desiccated at -20°C. Protect from light.
Therapeutic Area	Infectious Diseases
Use	A mitochondrial ATPase inhibitor use as antibiotics, antifungal activities.

Additional Information

Merck Index	13.6902.2001
MDL Number	MFCD00065705
ChemACX	X1094055-9
InChI	InChI=1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15+,21-18+/t25-,26-,27+,28+,29+,30-,31-,32-,33-,34-,35-,36-,38+,40+,41+,42-,44+,45-/m1/s1
SMILES	CC[C@H]1CC[C@@H]2[C@@H]([C@@H]([C@H]([C@@]3(O2)CC[C@H]([C@H](O3)C[C@H](C)O)C)C)OC(=O)/C=C/[C@H]([C@@H]([C@H](C(=O)[C@H]([C@@H]([C@H](C(=O)[C@@]([C@@H]([C@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C

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