nonactin cas 6833-84-7 ion select electrode ionphore application, ammonium-sele

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产品名称: nonactin cas 6833-84-7 ion select electrode ionphore application, ammonium-sele

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简单介绍

CAS:6833-84-7Formula:C40H64O12MW:736.93Appearance:WhitepowderPurity:96.5%

nonactin cas 6833-84-7 ion select electrode ionphore application, ammonium-sele 的详细介绍

Nonactin is a cyclic ionophore commonly produced by several species of Streptomyces which selectively binds K⁺ and NH₄⁺. Nonactin has been reported to inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is an uncoupler of oxidative phosphorylation and induces ATP hydrolysis at a concentration of 1x10^-7 M.

Nonactin has been shown to inhibit the production and gene transcription of IL-5 but not of IL-2 or IL-4. Nonactin has also been used as an ammonium ionophore for ammonium ion determination in a potentiometric electrode for biosensor construction as well as in a fluorescent immuno assay to detect K⁺ ions in pharmaceutical samples.

In the presence of Thallus acetate, Nonactin has further stimulated the swelling of rat liver mitochondria than thallus acetate alone. It also has shown to inhibit the effects on P170 glycoprotein-mediated efflux of chemotherapeutic agents in MDR cancer cells.

Additional Information

Product #	N-1155
CAS #	6833-84-7
Chemical Name	(1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-OCTAMETHYL-4,13,22,31,37,38,39,40-OCTAOXAPENTACYCLO[32.2.1.17,10.116,19.125,28]TETRACONTANE-3,12,21,30-TETRONE
Formula	C₄₀H₆₄O₁₂
MW	736.93
Appearance	White powder
Purity	96.5%
Solubility	soluble in CH₂Cl₂/DMSO: Clear colorless solution at 10 mg/ml
Melting Point	146°
Storage Temp	Store at -20°C. PROTECT FROM MOISTURE!
Use	Macrotetrolide antibiotic which acts as a monovalent cation ionophore and demonstrates high selectivity for ammonium and potassium

Additional Information

MDL Number	MFCD03267283
ChemACX	X1009767-7
InChI	InChI=1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1-8H3/t21-,22+,23+,24-,25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-
SMILES	C[C@@H]1C[C@H]2CC[C@H](O2)[C@@H](C(=O)O[C@H](C[C@@H]3CC[C@@H](O3)[C@H](C(=O)O[C@@H](C[C@H]4CC[C@H](O4)[C@@H](C(=O)O[C@H](C[C@@H]5CC[C@@H](O5)[C@H](C(=O)O1)C)C)C)C)C)C)C

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