Niclosamide

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产品名称: Niclosamide

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简单介绍

CAS:50-65-7Formula:CHClNOMW:327.12Appearance:Off-whitetopaleyellowSolidPurity:98%byHPLC

Niclosamide 的详细介绍

A STAT3 signaling pathway inhibitor. Niclosamide potently inhibits the activation and transcriptional function of STAT3 and induces cell growth inhibition, apoptosis, and cell cycle arrest of cancer cells with constitutively active STAT3. Also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro; displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.

Additional Information

Synonyms	5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Product #	N-1219
CAS #	50-65-7
Chemical Name	5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Formula	CHClNO
MW	327.12
Appearance	Off-white to pale yellow Solid
Purity	98% by HPLC
Solubility	Soluble in DMSO (10 mM) or Ethanol (25 mM)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Niclosamide displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells

Additional Information

MDL Number	MFCD00057597
ChemACX	X1038740-1
InChI	InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
SMILES	c1cc(c(cc1[N+](=O)[O-])Cl)NC(=O)c2cc(ccc2O)Cl

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