Necrostatin-5

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产品名称: Necrostatin-5

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简单介绍

CAS:337349-54-9Formula:C19H17N3O2S2MW:383.5Appearance:Whitetooff-whiteSolidPurity:98%(NMR)

Necrostatin-5 的详细介绍

Inhibits non-apoptotic cell deathpathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved in necroptosis, the alternative active cell death pathway: T-loop dependent inhibition by necrostatin-1; partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5A.

Additional Information

Synonyms	Nec-5
Product #	N-1229
CAS #	337349-54-9
Chemical Name	3-p-MEthoxyphenyl-5,6-tetramethylenothieno[2,3-d] pyrimidin-4-one-2-mercaptoethylcyanide
Formula	C₁₉H₁₇N₃O₂S₂
MW	383.5
Appearance	White to off-white Solid
Purity	98% (NMR)
Solubility	Soluble in DMSO (10mg/ml)
Storage Temp	-20°C
Use	Necrostatin-5 is an inhibitor of necroptosis by indirect inhibition of RIP1 kinase

Additional Information

MDL Number	MFCD01448275
ChemACX	X1708411-0
InChI	InChI=1S/C19H17N3O2S2/c1-24-13-8-6-12(7-9-13)22-18(23)16-14-4-2-3-5-15(14)26-17(16)21-19(22)25-11-10-20/h6-9H,2-5,11H2,1H3
SMILES	COc1ccc(cc1)n2c(=O)c3c4c(sc3nc2SCC#N)CCCC4

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