Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in mitochondria. Selectively blocks oxidative stress-induced necrotic death (0.1M Necrosis Inhibitor 5, prevented 50% cell death in H9C2 cells exposed to 400M t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or Etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as, CCL4- induced acute liver and chronic liver fibrosis in rodent models.in vitro Cell-based assays: Cold Stress, Hypoxia, Oxidative Stress.in vivo Necrosis Animal Models for Liver disease: DILI (Acetaminophen, CCL4), CCL4 induced Liver Fibrosis/Cirrhosis.Ischemia Reperfusion Injury: Stroke, Myocardial Infarction, Acute Pancreatitis Acute Tubular Necrosis.Cell Media: Cell Therapy
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