MPA CAS# 24280-93-1 Enteric coated mycophenolate sodium Enteric coated mycophen

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产品名称: MPA CAS# 24280-93-1 Enteric coated mycophenolate sodium Enteric coated mycophen

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简单介绍

CAS:24280-93-1Formula:C17H20O6MW:320.3Appearance:Whitetooff-whitePowderPurity:98%

MPA CAS# 24280-93-1 Enteric coated mycophenolate sodium Enteric coated mycophen 的详细介绍

Immunosuppressive agent. Mycophenolic acid (MPA) has been tested extensively in renal transplant patients and has been shown to be effective in reducing the incidence of acute graft rejection. MPA is now being evaluated in combinations with tacrolimus. It selectively inhibits lymphocyte proliferation by blocking the enzyme, inosine monophosphate dehydrogenase, part of in the guanosine monophosphate pathway.

This enzyme is involved in the de novo synthesis of purine nucleotides¹.

1.) Methanol-Associated Matrix Effects in Electrospray Ionization Tandem Mass Spectrometry.Quantification of Mycophenolic Acid and Glucuronide Metabolite in Human Serum by HPLC-Tandem Mass Spectrometry.

Additional Information

Synonyms	MPA, mycophenolate mofetil (MMF)
Product #	M-1036
CAS #	24280-93-1
Chemical Name	6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
Formula	C₁₇H₂₀O₆
MW	320.3
Appearance	White to off-white Powder
Purity	98%
Solubility	Soluble in ethanol (>10 mg/ml), DMSO (20 mg/ml), DMF (30 mg/ml), and 1:1 DMSO:PBS (pH 7.2) (~0.5 mg/ml). Insoluble in water
Melting Point	141°C
Storage Temp	+4°C
Therapeutic Area	Autoimmune Diseases
Use	Mycophenolic acid is an immunosuppressant drug used to prevent rejection in organ transplantation

Additional Information

Merck Index	13.6352.2001
MDL Number	MFCD00036814
ChemACX	X1002405-4
InChI	InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)
SMILES	Cc1c2c(c(c(c1OC)CC=C(C)CCC(=O)O)O)C(=O)OC2

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