mTOR Inhibitor, Ku-0063794

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产品名称: mTOR Inhibitor, Ku-0063794

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简单介绍

CAS:938440-64-3Formula:C25H31N5O4MW:465.54Appearance:PaleyellowSolidPurity:98%byHPLC

mTOR Inhibitor, Ku-0063794 的详细介绍

A potent mTOR (mammalian target of rapamycin) inhibitor (IC= ~10 nM for mTORC1 and mTORC2, respectively). Displays no activity against PI 3-kinase or 76 other kinases tested.

Additional Information

Synonyms	rel-5-[2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
Product #	M-2359
CAS #	938440-64-3
Chemical Name	rel-5-[2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
Formula	C₂₅H₃₁N₅O₄
MW	465.54
Appearance	Pale yellow Solid
Purity	98% by HPLC
Solubility	DMSO
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	A FRAP (mTOR) inhibitor for both mTORC1 and Mtorc2 in cancer

Additional Information

MDL Number	MFCD22666594
ChemACX	X1759489-7
InChI	InChI=1S/C25H31N5O4/c1-16-13-30(14-17(2)34-16)25-27-23-20(24(28-25)29-8-10-33-11-9-29)5-6-21(26-23)18-4-7-22(32-3)19(12-18)15-31/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17+
SMILES	C[C@@H]1CN(C[C@@H](O1)C)c2nc3c(ccc(n3)c4ccc(c(c4)CO)OC)c(n2)N5CCOCC5

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