Monastrol

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产品名称: Monastrol

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简单介绍

Formula:C14H16N2O3SMW:292.4Appearance:WhiteSolidPurity:95%

Monastrol 的详细介绍

Monastrol is a potent, cell permeable non-tubulin-interacting mitosis inhibitor. Monastrolblocks mitosis (IC= 14 M) by binding to the mitotic kinesin Eg5, a motor protein required for spindle bipolarity.Seeking published researchers utilizing our Monastrol product? Hit the link for the full paper.MCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachment.Functional Analysis of Human Microtubule-based Motor Proteins, the Kinesins and Dyneins, in Mitosis/Cytokinesis Using RNA Interference.

Additional Information

Synonyms	4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic acid ethyl ester
Product #	M-1116
Chemical Name	4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic acid ethyl ester
Formula	C₁₄H₁₆N₂O₃S
MW	292.4
Appearance	White Solid
Purity	95%
Solubility	Soluble in 100% ethanol and DMSO.
Melting Point	184 °C
Storage Temp	-20°C

Additional Information

MDL Number	MFCD00813077
ChemACX	X1342912-2
InChI	InChI=1S/C14H16N2O3S/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17H,3H2,1-2H3,(H2,15,16,20)
SMILES	CCOC(=O)C1=C(NC(=S)NC1c2cccc(c2)O)C

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