Mitomycin C, in NaCl CAS 50-07-7 Stem cells reagent hESCs | AG Sci

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产品名称: Mitomycin C, in NaCl CAS 50-07-7 Stem cells reagent hESCs | AG Sci

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简单介绍

CAS:50-07-7Formula:C15H18N4O5MW:334.3Appearance:Blue-VioletPurity:95.0%TLC,

Mitomycin C, in NaCl CAS 50-07-7 Stem cells reagent hESCs | AG Sci 的详细介绍

Mitomycin C is produced by a strain of actinomyces, Streptomyces caespitosus. It contains three anticancer moieties, quinine, urethane, and aziridine groups. It is used to generate mitotically inactive feeder cells in cell culture systems, such as the mitotically inactive fibroblasts used in embryonic stem cell systems.

This product is an alkylating agent that specifically targets the guanine nucleoside sequence 5′-CpG-3′. It inhibits DNA synthesis by covalently reacting with DNA, forming crosslinks between complementary strands of DNA. This interaction prevents separation of complementary DNA strands, inhibiting DNA replication.

Mitomycin C has strong antitumor activity, especially against Ehrlich ascites tumor cells, and strong bactericidal action against gram-positive and gram-negative bacteria.

This formulation consists of 2mg Mitomycin C in 48mg NaCl. This is not a sterile formulation.Refer to M1108 for our standard Mitomycin C product.

Additional Information

Product #	M-1130
CAS #	50-07-7
Chemical Name	[(1AS,8S,8AR,8BS)-6-AMINO-8A-METHOXY-5-METHYL-4,7-DIOXO-1,1A,2,4,7,8,8A,8B-OCTAHYDROAZIRENO[2',3':3,4]PYRROLO[1,2-A]INDOL-8-YL]METHYL CARBAMATE
Formula	C₁₅H₁₈N₄O₅
MW	334.3
Appearance	Blue -Violet
Purity	95.0% TLC,
Solubility	Soluble in Methanol and Water
Storage Temp	+4°C
Therapeutic Area	Oncological Disorders
Use	A DNA crosslinking agent that inhibits DNA synthesis and induces apoptosis in a variety of cells use in cancer

Additional Information

Merck Index	Merck Index: 13.6236[p.2001
MDL Number	MFCD00078109
ChemACX	X1004059-0
InChI	InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
SMILES	CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N

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