MIF-Antagonist, ISO-1

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产品名称: MIF-Antagonist, ISO-1

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简单介绍

CAS:478336-92-4Formula:C12H13NO4MW:235.24Appearance:Off-WhiteSolidPurity:98%byHPLC

MIF-Antagonist, ISO-1 的详细介绍

Cell-permeable. A macrophage migration inhibitory factor (MIF) antagonist. ISO-1 inhibits MIF pro-inflammatory activities by targeting MIF tautomerase activity. Also inhibits tumor necrosis factor (TNF) release from macrophages isolated from LPS- treated wild type mice but has no effect on cytokine release from MIF deficient macrophages.

Additional Information

Synonyms	(S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester
Product #	M-2379
CAS #	478336-92-4
Chemical Name	(S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester
Formula	C₁₂H₁₃NO₄
MW	235.24
Appearance	Off-White Solid
Purity	98% by HPLC
Solubility	Soluble in DMSO (~25 mg/ml)
Melting Point	133.69 °C
Storage Temp	-20°C
Therapeutic Area	Endocrinological Disorders
Use	MIF Antagonist, ISO-1 has been shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic

Additional Information

MDL Number	MFCD22376813
ChemACX	X4983373-6
InChI	InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3
SMILES	COC(=O)CC1CC(=NO1)c2ccc(cc2)O

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