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Micrococcin P1,MP1

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产品名称: Micrococcin P1,MP1
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简单介绍

CAS:67401-56-3Formula:C48H49N13O9S6MW:1144.4Appearance:Off-whitetolightfawnPurity:>95%byHPLC


Micrococcin P1,MP1  的详细介绍

*Please inquire the availability for this product. Micrococcin P1 holds the remarkable position in antibiotic discovery as the first of the early antibiotics to be lost to science. Micrococcin P1 is a thiopeptide originally isolated from Micrococcus sp. by Su at Oxford in 1948. Later, Heatley and Doery purified micrococcin and defined its physico-chemical properties and activity. The producing strain was lost, causing a hiatus in research of this antibiotic family until the discovery of the related thiocillins in 1976.

Micrococcin P1 demonstrates potent antimicrobial activity against bacteria, fungi, and even protozoa. Because it is a thiopeptide, Micrococcin P1(MP1) hold the potential for natural product engineering and avoid the growing concern of antibiotic resistance. 

Additional Information

SynonymsMP1
Product #M-2581
CAS #67401-56-3
FormulaC48H49N13O9S6
MW1144.4
AppearanceOff-white to light fawn
Purity>95% by HPLC
Therapeutic AreaInfectious Diseases
UseMicrococcin P1, is an antibiotic that exhibits noteworthy antibacterial, antiprotozoal, antimalarial activities

Additional Information

InChIInChI=1S/C48H49N13O9S6/c1-8-24(37(65)49-12-20(5)62)51-38(66)28-15-73-46(56-28)32-18-74-45(58-32)26-11-10-23-36(50-26)27-13-75-48(53-27)35(22(7)64)61-41(69)31-17-76-47(57-31)33(19(3)4)59-39(67)30-16-72-44(55-30)25(9-2)52-42(70)34(21(6)63)60-40(68)29-14-71-43(23)54-29/h8-11,13-22,33-35,62-64H,12H2,1-7H3,(H,49,65)(H,51,66)(H,52,70)(H,59,67)(H,60,68)(H,61,69)/b24-8-,25-9-/t20-,21-,22-,33+,34+,35+/m1/s1
SMILESC/C=C\1/c2nc(cs2)C(=O)N[C@H](c3nc(cs3)C(=O)N[C@H](c4nc(cs4)-c5c(ccc(n5)c6nc(cs6)c7nc(cs7)C(=O)N/C(=C\C)/C(=O)NC[C@@H](C)O)-c8nc(cs8)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)[C@@H](C)O)C(C)C
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