MC1568 interferes with myogenic signaling by blocking HDAC enzymatic activity and MEF2-mediated transactivation in C2C12 cells. Exposure of rat intestinal epithelial cell line EIC-18 to MC1568 prevented stimulation of DNA synthesis and blocked cell cycle progression in the G0/G1 phase. In a mice carotid ligation model, MC1568 has been shown to mediate proliferation and migration of smooth muscle cells in vitro, and thus may reduce blood pressure in hypertensive animals.
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