Latrunculin B 76343-94-7 | Actin Filament Modulr | impairs ultrafast endocytosi

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产品名称: Latrunculin B 76343-94-7 | Actin Filament Modulr | impairs ultrafast endocytosi

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简单介绍

CAS:76343-94-7Formula:C20H29NO5SMW:395.5Appearance:LyophilizedSolidPurity:98%

Latrunculin B 76343-94-7 | Actin Filament Modulr | impairs ultrafast endocytosi 的详细介绍

Latrunculin B is an actin filament modulator. 10 to 100-fold more potent than cytochalasins. Where cytochalasin D induces dissolution of F-actin and stress fiber contraction in fibroblasts in culture.Latrunculin B causes stress fibers toshortening and thicken.EffectsN1E-115 cells (mouse neuroblastoma) at starting concentrationsof 90 nM (NI43T3 cells, 0.9M). Maximumeffect at 2.5M. Fetal Bovine serum will slowly inactivate. Inhibitscofilin-actin binding (ED~50 M).Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes.Cytoskeletal remodeling in differentiated vascular smooth muscle is actin isoform dependent and stimulus dependent.Differential Involvement of the Actin Cytoskeleton in Differentiation and Mitogenesis of Thyroid Cells: Inactivation of Rho Proteins Contributes to Cyclic Adenosine Monophosphate-Dependent Gene Expression but Prevents Mitogenesis.A Role for Cytoskeletal Elements in the Light-Driven Translocation of Proteins in Rod Photoreceptors.The Potato Virus X TGBp2 Movement Protein Associates with Endoplasmic Reticulum-Derived Vesicles during Virus Infection.

Additional Information

Synonyms	Latrunculin B, Actin filament modulator.
Product #	L-1057
CAS #	76343-94-7
Chemical Name	(4R)-4-[(1R,4Z,8Z,10S,13R,15R)-15-HYDROXY-5,10-DIMETHYL-3-OXO-2,14-DIOXABICYCLO[11.3.1]HEPTADECA-4,8-DIEN-15-YL]-1,3-THIAZOLIDIN-2-ONE
Formula	C₂₀H₂₉NO₅S
MW	395.5
Appearance	Lyophilized Solid
Purity	98%
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).
Melting Point	258.13 °C
Storage Temp	-20°C
Use	Latrunculin B is a structurally unique marine toxin

Additional Information

Merck Index	Merck Index: 14: 5378
MDL Number	MFCD00270879
ChemACX	X1000493-6
InChI	InChI=1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13?,15-,16?,17-,20-/m1/s1
SMILES	CC/1CC[C@@H]2CC(C[C@@](O2)([C@H]3CSC(=O)N3)O)OC(=O)/C=C(CC/C=C1)/C

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